Handbook of Analysis of Oligonucleotides and Related Products (2024)

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angličtina [en], .pdf, lgli/lgrs/zlib, 15.6MB, 📘 Kniha (literatúra faktu), _511284.4ecfb90f4c4400c9df95d062b2b570c6

Handbook of Analysis of Oligonucleotides and Related Products 🔍

CRC Press, 1, 2011

Jose V. Bonilla, G. Susan Srivatsa 🔍

description

“Oligonucleotides represent one of the most significant pharmaceutical breakthroughs in recent years, showing great promise as diagnostic and therapeutic agents for malignant tumors, cardiovascular disease, diabetes, viral infections, and many other degenerative disorders. The Handbook of Analysis of Oligonucleotides and Related Products is an essential reference manual on the practical application of modern and emerging analytical techniques for the analysis of this unique class of compounds. A strong collaboration among thirty leading analytical scientists from around the world, the book provides readers with a comprehensive overview of the most commonly used analytical techniques and their advantages and limitations in assuring the identity, purity, quality, and strength of an oligonucleotide intended for therapeutic use. Topics discussed include: Strategies for enzymatic or chemical degradation of chemically modified oligonucleotides toward mass spectrometric sequencing Purity analysis by chromatographic or electrophoretic methods, including RP-HPLC, AX-HPLC, HILIC, SEC, and CGE Characterization of sequence-related impurities in oligonucleotides by mass spectrometry and chromatography Structure elucidation by spectroscopic methods (IR, NMR, MS) as well as base composition and thermal melt analysis (Tm) Approaches for the accurate determination of molar extinction coefficient of oligonucleotides Accurate determination of assay values Assessment of the overall quality of oligonucleotides, including microbial analysis and determination of residual solvents and heavy metals Strategies for determining the chemical stability of oligonucleotides The use of hybridization techniques for supporting pharmaco*kinetics and drug metabolism studies in preclinical and clinical development Guidance for the presentation of relevant analytical information towards meeting current regulatory expectations for oligonucleotide therapeutics This resource provides a practical guide for applying state-of-the-art analytical techniques in research, development, and manufacturing settings.”

metadata comments

“Includes bibliographical references and index.

index is missing

2011 12 30

lg742304”

date open sourced

2012-02-04 (ol_source: 2010-12-09, isbndb_scrape: 2022-09-01, lgli_source: 2012-02-04, zlib_source: 2019-04-08, lgrsnf_source: 2012-02-04)

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